Thursday, November 7, 2013

Stanford Professor Who Sounded Alert On Multitasking Has Died





The question of how humans process the flood of electronic media was a central part of the work of Stanford University sociology professor Clifford Nass, who died recently. Citing multiple studies, Nass said people often overestimate their ability to multitask.



iStockphoto.com


The question of how humans process the flood of electronic media was a central part of the work of Stanford University sociology professor Clifford Nass, who died recently. Citing multiple studies, Nass said people often overestimate their ability to multitask.


iStockphoto.com


Clifford Nass, the Stanford University sociologist who helped pioneer studies that undermined ideas about multitasking, has died at age 55. The man who dedicated his career to thinking about how humans live in a digital age died after taking part in a hike near Lake Tahoe Saturday.


At Stanford, Nass was "a larger than life character," his colleague professor Byron Reeves tells NPR's All Things Considered. Reeves says Nass "was just incredibly enthusiastic about his work, about students."


As for Nass' legacy, Reeves says his colleague worked to trace how technology has moved "from tools to social actors," in which everything from robots and computer-laden cars can now use interactive software to present visual cues.


"These were essentially social responses," Reeves says. "And humans were built for those kinds of social responses, and to recognize that kind of social interaction and to participate... and they did."


A graduate of Princeton University with degrees in mathematics and sociology, Nass worked as a computer scientist at Intel Corp. before beginning his work at Stanford, according to the Stanford Report. The school paper adds, "He was also a professional magician."


Nass's work on multitasking was just one part of how he examined the way people interact with technology. He also wrote books about voice recognition software, and the ways people think about computers and television.


But it was his research — and his skepticism — about multitasking that drew the most notice. And Nass didn't have to look far for test subjects.


"The top 25 percent of Stanford students are using four or more media at one time whenever they're using media," he told NPR's Science Friday this past May. "So when they're writing a paper, they're also Facebooking, listening to music, texting, Twittering, et cetera. And that's something that just couldn't happen in previous generations even if we wanted it to."


To anyone who claims they're able to multitask, to concentrate on multiple things at once while still thinking creatively and using their memory, Nass had a ready response.


"They're basically terrible at all sorts of cognitive tasks, including multitasking," he told Science Friday's Ira Flatow, citing a raft of scientific research. In Nass's view, people who say they're good at multitasking because they do it all the time are like smokers who say they've always smoked — so it can't be bad form them.


"People who multitask all the time can't filter out irrelevancy. They can't manage a working memory. They're chronically distracted," Nass said. "They initiate much larger parts of their brain that are irrelevant to the task at hand. And even - they're even terrible at multitasking. When we ask them to multitask, they're actually worse at it. So they're pretty much mental wrecks."


Nass also warned that the mental strain of taking in an ever-increasing load of information through electronic media hasn't been fully realized.


"Companies now create policies that force their employees to multitask," he said, according to the Stanford Report. "It's an OSHA (Occupational Safety and Health Administration) problem. It's not safe for people's brains."


Another of Nass' experiments revolved around how people see virtual versions of themselves — particularly when given the option of giving themselves feedback. Here's how he explained the results of a study during a 2010 appearance on NPR:




"We've done studies, for example, in which... you take a test on a computer and the feedback is either given not only by your own voice but your own face, saying you did a good job or you did a bad job, or someone else has.


"And people not only thought they did better when they got feedback from their own voice, they thought their own face and voice was more intelligent, more likable, and in fact they remembered more of the positive and fewer of the negative comments."




Source: http://www.npr.org/blogs/thetwo-way/2013/11/07/243762058/stanford-professor-who-sounded-alert-on-multitasking-has-died?ft=1&f=1001
Category: brandon marshall   john lennon   homeland   new england patriots   tommy morrison  

Kate Upton Strips down to the Paint

Showing the fashion world that it has nothing on her, the irresistibly sexy Kate Upton posed for a nude body paint photo shoot for Sports Illustrated Magazine.


Looking perfect, and showing off her signature curves without the burdens of clothing, the 21-year-old said at the beginning of the shoot, "The day here is perfect. The weather is amazing, and I'm happy to take off my clothes just for a little warm weather!"


The sensual supermodel sported an intricately painted bikini, which acted as a throwback to the cover of the swimsuit edition's 2000 model, Daniela Pestova.


"I definitely feel naked," the GQ covergirl said during the shoot. "Because I am. It's just paint! She posed in several different stances, and her artists gave a brief description of how difficult and elaborate her painted swimsuit was to create. Watch below!






Source: http://celebrity-gossip.net/kate-upton/kate-upton-strips-down-paint-957352
Category: Jaimie Alexander   reggie wayne   Tom Clancy   Ios 7 Release Date   brandon jacobs  

Apple updates iBooks for Mavericks with bug fixes

Apple updates iBooks for Mavericks with bug fixes

Apple has posted iBooks Update 1.0.1 for Mac users who are using OS X 10.9 Mavericks. The update is available through Software Update.

The update sports typically terse Apple release notes:

This version of iBooks includes bug fixes and improvements to performance and stability.


    






Source: http://feedproxy.google.com/~r/TheIphoneBlog/~3/aP7wdzrX-lo/story01.htm
Category: Jaimie Alexander   hocus pocus   chicago marathon   Cressida Bonas   9/11 Memorial  

Roy Choi's Tacos Channel 'LA' And The Immigrant Experience





Chef Roy Choi was named Food and Wine Magazine's Best New Chef in 2010.



Bobby Fisher/Courtesy of Harper Collins


Chef Roy Choi was named Food and Wine Magazine's Best New Chef in 2010.


Bobby Fisher/Courtesy of Harper Collins


Roy Choi is a chef who's celebrated for food that isn't fancy. He's one of the founders of the food truck movement, where instead of hot dogs or ice cream, more unusual, gourmet dishes are prepared and sold. His Kogi trucks specialize in tacos filled with Korean barbeque.


Choi was born in South Korea in 1970 and moved to Los Angeles with his parents at the age of 2. His parents owned a Korean restaurant near Anaheim for a few years when he was a child. He tells Fresh Air's Terry Gross that his mother had some serious cooking talent.


"She had flavor in her fingertips," he says. "She had this connection and this innate ability to capture flavor in the moment and people felt it. Because our lives were so based around food, when someone is good at food, everyone notices and it's a big deal."





Customers line up at one of Roy Choi's Kogi BBQ food trucks near the campus of UCLA.



Matt Sayles/AP


Customers line up at one of Roy Choi's Kogi BBQ food trucks near the campus of UCLA.


Matt Sayles/AP


Choi's new book, L.A. Son: My Life, My City, My Food, is part memoir, part cookbook.



Interview Highlights


On what Korean tacos represent for him


The Korean taco was a phenomenon. ... It just came out of us, we didn't really think about it. The flavor, in a way, didn't exist before, but it was a mash up of everything we had gone through in our lives.


It became a voice for a certain part of Los Angeles and a certain part of immigration and a certain part of life that wasn't really out there in the universe. We all knew it and we all grew up with it, and it was all around us, but the taco kind of pulled it together. It was like a lint roller; it just put everything onto one thing. And then when you ate it, it all of a sudden made sense.


As I was putting it together, it was all of the pieces of my life coming together. It was almost like an avalanche. So it was growing up; it was being around low-riding; it was growing up in Korea, the immigration, being around the American school system; all the snack food and junk food that I've eaten; all of the tacos that I've eaten. It was all of these things. Then I really wanted to make it feel like Los Angeles, so I felt like it had to be just like a street taco in L.A.



On his Hawaiian restaurant, A-Frame, which is housed in an old IHOP


It's my love for the Hawaiian Islands, but it's not a tiki restaurant: It's really taking the feeling of "aloha." So we put people together, it's all communal seating, so strangers get to sit together. ... You eat everything with your hands and it's like a backyard barbeque.


... I wasn't always the most professional looking/acting dude in the world, so I'd go into restaurants, get treated not that well, kind of like crap. So what happened was I thought, "OK, if I ever make a restaurant, as soon as anyone opens that door, no matter where you're from, I want you to feel like we've been waiting for you."


On his rice bowl restaurant, Chego


That's a real personal place. ... A lot of Asian-Americans, growing up, we kind of live double lives. We had our refrigerators at home and the way we ate at home, and then we went to school and we couldn't really show that food because it was real stinky and stuff like that.


When you're going through that whole puberty/teenage angst ... you don't want to show that. Chego was my vision to show that food, to open the refrigerator, to show it to the world, and then make these rice bowls that were under $10. So it was also a platform to create great, delicious, healthy fast food that's affordable.


On growing up in Orange County and the cultural differences between his family and his friends


I was doomed because everyone had peroxide in their hair and they were coming from ski trips on Mammoth Mountain and snorkeling trips in the Cayman Islands, listening to Depeche Mode and The Cure, and I had never seen anything like that before. It wasn't really my rhythm.



A lot of Asian-Americans, growing up, we kind of live double lives. We had our refrigerators at home and the way we ate at home, and then we went to school and we couldn't really show that food because it was real stinky ...



I did the best I could. I was doomed because there weren't that many Asians and girls weren't really feeling me, but I was also doomed because if we get down to the food, the food was different for me too. I was embarrassed to show the food [we were eating] because everywhere I went, it was so different. Youngsters are mean to each other sometimes so I'd bring friends over and they'd look at my food and they'd be like, "Ew, what is that?"


... When you bring a bunch of rich friends from Orange Country over to your house and your whole house is surrounded by dead salted fish, it was tough.


... I loved it at the time. When I say the word "embarrassed" it's not that I was embarrassed and that I tried to shy away from it or that I tried to put it into the dirt and hope that it never came out again; it's just I didn't have the language to really stick up for it at that time.



On his addictions


Gambling hit me at like 22, 21. And it was three years of the darkest time of my life, but it started out just all fireworks and pom-poms, you know?


It was an amazing ride for the first year, I mean tens of thousands of dollars in shoeboxes ... just ballin' crazy. ... And then I started losing. And when you start losing in gambling, then you start chasing it. ... I lost all my friends; I lost all my family; I stole from my family ... sold everything I had.


... I'm addicted to feeding people right now. It's a good thing. I don't know how long this is gonna last right now, so I'm living it up and really focusing and putting everything I got into it. I'm putting my back into it.



Source: http://www.npr.org/2013/11/07/243527051/roy-chois-tacos-channel-la-and-the-immigrant-experience?ft=1&f=1032
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Time's odd cover treatment of Christie


This week's Time magazine features three articles on New Jersey Gov. Chris Christie, whose landslide re-election Tuesday "instantly christened him the GOP frontrunner for 2016." The issue includes an accompanying story by MSNBC host Joe Scarborough, who compares Christie to Ronald Reagan and Bruce Springsteen.

"For a pro-life conservative running in a deep blue state, it was a performance every bit as dominant as the Boss ripping through a live version of 'Rosalita,'" Scarborough writes. "And like Springsteen himself, Christie made it all look easy."

But it's the cover that's likely to get the most attention.

It shows a shadowy silhouette of Christie's profile above the coverline "The Elephant in the Room," a reference to both the Republican Party's mascot and the GOP hopeful's weight.

Christie's weight has long been tied to his political ambitions, with some fearing it could be a health concern for voters.

According to "Double Down," a new book by Mark Halperin and John Heilemann about the 2012 presidential campaign, Republican nominee Mitt Romney passed on picking Christie as a vice presidential running mate in part because of his weight.

But the governor has since taken steps to shed pounds.

Christie underwent lap-band surgery in February. On Tuesday, he told the New York Times he is more than halfway to meeting his weight-loss goal, and that he's sleeping better as a result. "I didn’t realize how badly I was sleeping being that much overweight," Christie said. (His appetite is so small these days, he said, he "recently could not even finish a wrap sandwich.")

He's also long poked fun at his outsized frame. In February, he said his weight is "fair game" for comedians. In an appearance on "The Late Show with David Letterman" earlier this year, Christie consumed a doughnut during the interview.

And when asked by the Times if he would have trouble handling the rigors of a presidential campaign, Christie replied, “No more than any other 51-year-old person. I’m slower than I was when I was 40. But that’s the slow march of time."

The Nov. 18 issue with Christie on the cover is due on newsstands Friday.

Of course, it's not the first time Time has courted controversy.

Last year, the magazine sparked a firestorm with a cover featuring a 26-year-old woman breastfeeding her 3-year-old son.

Source: http://news.yahoo.com/time-christie-elephant-cover-134301047.html
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JFK's Caroline: keeper of family flame, diplomat


WASHINGTON (AP) — She is the little girl riding her pony Macaroni around the White House lawn, the big sister hiding under the Oval Office desk with her little brother John. And in a heartbreaking childhood photo, she is the white-gloved daughter kneeling with her mother at the coffin of her slain father, the president.

Flash forward 50 years and here is Caroline Kennedy again: author, lawyer and mother of three, tending to the Kennedy flame as her family's sole survivor. And, finally, after decades protecting her privacy, she's stepping into a more public role as U.S. ambassador to Japan.

Kennedy, 55, was five days short of her sixth birthday when John F. Kennedy was assassinated on Nov. 22, 1963.

The family's nanny gently informed Caroline that her father had been shot "and they couldn't make him better."

With that, Caroline's world was shaken, not for the first time or the last.

Three months earlier, a little brother, Patrick, had died shortly after birth. Then Robert F. Kennedy, the uncle who stepped in to serve as a sort of surrogate father after JFK's assassination, was himself shot and killed five years later. After losing her mother to cancer in 1994, Caroline lost her brother John in a 1999 plane crash at age 38.

Through it all, level-headed Caroline soldiered on, lending her support to the causes and ideals her parents and brother had championed. She's served as president of the John F. Kennedy Library Foundation and chaired the senior advisory committee of the Institute of Politics at Harvard, set up as a memorial to Kennedy,

Trey Grayson, director of the institute, describes Kennedy as quiet and down to earth, willing to be blunt when needed, and gracious at managing the daily challenges that come with nurturing her father's legacy.

"Every day, people walk up to her and say, 'I'm such a big fan of your father, he inspired me to do this,' and she's handled that so well," Grayson said.

Asked in 2012 if she ever felt overwhelmed by the legacy of the Kennedy years and the carefully cultivated image of a modern day Camelot, Kennedy said simply, "I can't imagine having better parents and a more wonderful brother. So I feel really fortunate that those are my family, and I wish they were here.

"But my own family, my children, my husband, are really my real family and so ... we're just us."

Raised in privilege on New York's Upper East Side, Kennedy earned a Columbia law degree but rather than practice law, she chose to write and edit books about the right to privacy, poetry and other subjects. While her brother made a public splash and earned the label "sexiest man alive" from People magazine, Caroline limited her public appearances and tried to be just another parent shepherding her kids to adulthood, working as an unpaid fundraiser for the city's school system once they got older. She is married to exhibit designer Edwin Schlossberg.

For all the days that felt just ordinary, though, there were moments when recollections of the trials of her life would come crashing through.

"You don't think about it all the time," Kennedy once said, in a comment cited in Christopher Andersen's biography "Sweet Caroline." ''Sometimes you're just walking down the street and it just hits you ...."

Over the years, she has gradually edged back into the spotlight, and stepped more deeply into politics.

Early in 2008, she endorsed Barack Obama in the presidential campaign, a pivotal moment in his primary race against Hillary Rodham Clinton; Kennedy later served on the team that helped Obama select his running mate.

But she abruptly withdrew after flirting with the idea of seeking appointment to the Senate seat vacated when Clinton became secretary of state, citing personal reasons. Kennedy had been harshly criticized for giving halting interviews and limiting her interactions with reporters, and some critics questioned whether her background had prepared her for the Senate.

Kennedy seemed far more comfortable with the job description when Obama last summer nominated her to serve as U.S. ambassador to Japan. She was unanimously confirmed by the Senate in October.

She is expected to take up her position in Japan by the end of the month.

___

Follow Benac on Twitter at http://www.twitter.com/nbenac

Source: http://news.yahoo.com/jfks-caroline-keeper-family-flame-diplomat-213700799.html
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FDA awards $2.25M grant to study immunosuppresive drug in high-risk patients

FDA awards $2.25M grant to study immunosuppresive drug in high-risk patients


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7-Nov-2013



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University of Cincinnati Academic Health Center



Retrospective and prospective studies will examine conversion to generic tacrolimus in transplant patients



CINCINNATITransplant researchers at the University of Cincinnati (UC) have received a grant from the U.S. Food and Drug Administration to study the safety and efficacy of a generic immunosuppressive drug in high-risk transplant patients.


Rita Alloway, PharmD, UC research professor of medicine and director of transplant clinical research within the UC Department of Internal Medicine, received a $2.25 million FDA grant to run two clinical trials studying the effects of immunosuppressant tacrolimus (Prograf and generics) in high-risk transplant patients.


Tacrolimus is a "cornerstone drug" in post-transplant immunosuppression, used after transplant to reduce the activity of the patient's immune system and lower the risk of rejection. Generic versions were introduced in 2009. Currently Alloway estimates more than 70 percent of transplant patients are dispensed generic tacrolimus.


"The largest concern for clinicians is the switchability between various generics," says Alloway. "When patients receive their prescription, they could be getting medication from different manufacturers each month. Most immunosuppressant drugs require individualized dosing and careful management to ensure the proper blood concentrations are maintainedtoo high exposure to these drugs increases the risk of toxicity, over-immunosuppression and cancer in patents. Too low exposure may lead to rejection of the organ by the patient's immune system."


The three-year grant will support retrospective and prospective studies in high-risk transplant recipients who have converted from branded tacrolimus to a generic version.


In the retrospective study, transplant recipients will be assessed one year prior and one year post conversion to the generic, with researchers assessing their tacrolimus dose changes, incidence of rejection, hospital admission, changes in renal function and changes in transplanted organ function.


The prospective study will compare the bioavailability and steady-state pharmacokinetics of six tacrolimus formulations in a six-way cross-over study. This study will compare patients who express the CYP3A5 enzyme and those who do not, as CYP3A5 expressors have been shown to require larger doses of tacrolimus to attain therapeutic blood concentrations.


Preliminary data from Alloway's tacrolimus research has suggested a link between CYP3A5 expression and peak tacrolimus levels after dosing in generic tacrolimus formulations.


"This study will analyze an enriched patient population based upon genetic factors which predispose the patient to be high risk and most likely to experience problems with generic switching if problems exist," states Alloway.


In 2012, Alloway received a $2.7 million grant from the FDA to study whether the two most disparate generic versions of tacrolimus are bioequivalent to the branded, or innovator, version of the drug in stable transplant patients.


"The results of these studies should address public concerns regarding the use of generic tacrolimus formulations in transplant recipients and provide the transplant clinician and recipients with objective data to address their concerns," she says.



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FDA awards $2.25M grant to study immunosuppresive drug in high-risk patients


[ Back to EurekAlert! ]

PUBLIC RELEASE DATE:

7-Nov-2013



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Contact: Katy Cosse
kathryn.cosse@uc.edu
513-558-0207
University of Cincinnati Academic Health Center



Retrospective and prospective studies will examine conversion to generic tacrolimus in transplant patients



CINCINNATITransplant researchers at the University of Cincinnati (UC) have received a grant from the U.S. Food and Drug Administration to study the safety and efficacy of a generic immunosuppressive drug in high-risk transplant patients.


Rita Alloway, PharmD, UC research professor of medicine and director of transplant clinical research within the UC Department of Internal Medicine, received a $2.25 million FDA grant to run two clinical trials studying the effects of immunosuppressant tacrolimus (Prograf and generics) in high-risk transplant patients.


Tacrolimus is a "cornerstone drug" in post-transplant immunosuppression, used after transplant to reduce the activity of the patient's immune system and lower the risk of rejection. Generic versions were introduced in 2009. Currently Alloway estimates more than 70 percent of transplant patients are dispensed generic tacrolimus.


"The largest concern for clinicians is the switchability between various generics," says Alloway. "When patients receive their prescription, they could be getting medication from different manufacturers each month. Most immunosuppressant drugs require individualized dosing and careful management to ensure the proper blood concentrations are maintainedtoo high exposure to these drugs increases the risk of toxicity, over-immunosuppression and cancer in patents. Too low exposure may lead to rejection of the organ by the patient's immune system."


The three-year grant will support retrospective and prospective studies in high-risk transplant recipients who have converted from branded tacrolimus to a generic version.


In the retrospective study, transplant recipients will be assessed one year prior and one year post conversion to the generic, with researchers assessing their tacrolimus dose changes, incidence of rejection, hospital admission, changes in renal function and changes in transplanted organ function.


The prospective study will compare the bioavailability and steady-state pharmacokinetics of six tacrolimus formulations in a six-way cross-over study. This study will compare patients who express the CYP3A5 enzyme and those who do not, as CYP3A5 expressors have been shown to require larger doses of tacrolimus to attain therapeutic blood concentrations.


Preliminary data from Alloway's tacrolimus research has suggested a link between CYP3A5 expression and peak tacrolimus levels after dosing in generic tacrolimus formulations.


"This study will analyze an enriched patient population based upon genetic factors which predispose the patient to be high risk and most likely to experience problems with generic switching if problems exist," states Alloway.


In 2012, Alloway received a $2.7 million grant from the FDA to study whether the two most disparate generic versions of tacrolimus are bioequivalent to the branded, or innovator, version of the drug in stable transplant patients.


"The results of these studies should address public concerns regarding the use of generic tacrolimus formulations in transplant recipients and provide the transplant clinician and recipients with objective data to address their concerns," she says.



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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.




Source: http://www.eurekalert.org/pub_releases/2013-11/uoca-fa110713.php
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